MovDisordV3, Main, Exploration, bibRecord, 005D54

PET study on striatal dopamine D2 receptor changes during the progression of early parkinson's disease

Identifieur interne : 005D54 ( Main/Exploration ); précédent : 005D53; suivant : 005D55

PET study on striatal dopamine D2 receptor changes during the progression of early parkinson's disease

Auteurs : Rinne [Finlande] ; A. Laihinen [Finlande] ; U. K. Rinne [Finlande] ; K. N Gren [Finlande] ; J. Bergman [Finlande] ; U. Ruotsalainen [Finlande]

Source :

Movement Disorders [ 0885-3185 ] ; 1993.

RBID : ISTEX:2B60C44A3E9373C96493CC323032DE0C74704742

English descriptors

KwdEn :
- Adult, Aged, Carbon Radioisotopes, Corpus Striatum (radionuclide imaging), D2 receptors, Dopamine, Dopamine D2 Receptor Antagonists, Female, Humans, Male, Middle Aged, Neurologic Examination, Parkinson Disease (radionuclide imaging), Parkinson's disease, Positron emission tomography, Raclopride, Receptors, Dopamine D2 (physiology), Salicylamides (diagnostic use), Salicylamides (pharmacokinetics), Tomography, Emission-Computed, Up-Regulation (physiology).
MESH :
- chemical , diagnostic use : Salicylamides.
- chemical , pharmacokinetics : Salicylamides.
- chemical , physiology : Receptors, Dopamine D2.
- chemical : Carbon Radioisotopes, Dopamine D2 Receptor Antagonists, Raclopride.
- physiology : Up-Regulation.
- radionuclide imaging : Corpus Striatum, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neurologic Examination, Tomography, Emission-Computed.

Abstract

[11C] Raclopride uptake to dopamine D2 receptors was investigated with positron emission tomography (PET) in patients with early Parkinson's disease at the time of the diagnosis and after a half‐year interval. During this progressive period of the disease, the patients received no antiparkinsonian medication. The upregulation of striatal D2 receptors, which was seen in all patients already at the time of the diagnosis, persisted. Although the patients initially showed unilateral disease, they had developed bilateral symptoms by the time of the second PET scan, but the disease was still asymmetric. The present results show that the relative increase in [11C]raclopride uptake in the striatum contralateral to the symptoms as compared with the opposite striatum will be preserved even during the progression of the disease, provided that the symptoms show clear‐cut asymmetry.

Url:

https://api.istex.fr/document/2B60C44A3E9373C96493CC323032DE0C74704742/fulltext/pdf

DOI: 10.1002/mds.870080203

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">[11C] Raclopride uptake to dopamine D2 receptors was investigated with positron emission tomography (PET) in patients with early Parkinson's disease at the time of the diagnosis and after a half‐year interval. During this progressive period of the disease, the patients received no antiparkinsonian medication. The upregulation of striatal D2 receptors, which was seen in all patients already at the time of the diagnosis, persisted. Although the patients initially showed unilateral disease, they had developed bilateral symptoms by the time of the second PET scan, but the disease was still asymmetric. The present results show that the relative increase in [11C]raclopride uptake in the striatum contralateral to the symptoms as compared with the opposite striatum will be preserved even during the progression of the disease, provided that the symptoms show clear‐cut asymmetry.</div>
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Movement Disorders (revue)

PET study on striatal dopamine D2 receptor changes during the progression of early parkinson's disease

PET study on striatal dopamine D2 receptor changes during the progression of early parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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